ea0029p704 | Diabetes | ICEECE2012
Taylor-Fishwick D.
, Weaver J.
, Ganesha B.
, Holman T.
, Jadhav A.
, Maloney D.
, Nadler J.
, Simeonov A.
In this study we explore and integrate a pathway for loss of functional beta cell mass in diabetes. Inflammatory cytokines induce human islet dysfunction, elevate expression of 12-lipoxygenase, increase cellular reactive species and induce NADPH oxidase. These pathways are elevated in islets from diabetic donors.NADPH oxidase-1 (NOX-1) is significantly induced in either human donor islets, primary mouse islets or homogeneous beta cell lines following sti...